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4i2x

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'''Unreleased structure'''
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{{STRUCTURE_4i2x| PDB=4i2x | SCENE= }}
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===Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117===
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The entry 4i2x is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/SIRPG_HUMAN SIRPG_HUMAN]] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<ref>PMID:15383453</ref>
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Authors: Nettleship, J.E., Ren, J., Stuart, D.I., Owens, R.J., Oxford Protein Production Facility (OPPF)
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==About this Structure==
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[[4i2x]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I2X OCA].
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Description: Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Nettleship, J E.]]
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[[Category: OPPF, Oxford Protein Production Facility.]]
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[[Category: Owens, R J.]]
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[[Category: Ren, J.]]
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[[Category: Stuart, D I.]]
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[[Category: Cd47]]
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[[Category: Cell surface]]
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[[Category: Immune system]]
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[[Category: Oppf]]
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[[Category: Oxford protein production facility]]
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[[Category: Protein-fab complex]]
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[[Category: Signal regulatory protein]]
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[[Category: Structural genomic]]

Revision as of 10:35, 18 December 2013

Template:STRUCTURE 4i2x

Contents

Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117

Function

[SIRPG_HUMAN] Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.[1]

About this Structure

4i2x is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F, Cella M, Colonna M. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood. 2005 Mar 15;105(6):2421-7. Epub 2004 Sep 21. PMID:15383453 doi:10.1182/blood-2004-07-2823

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OCA

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