4iec

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'''Unreleased structure'''
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{{STRUCTURE_4iec| PDB=4iec | SCENE= }}
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===Cys105 covalent modification by 2-hydroxyethyl disulfide in Mycobacterium tuberculosis methionine aminopeptidase Type 1c===
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The entry 4iec is ON HOLD until Dec 13 2014
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==Function==
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[[http://www.uniprot.org/uniprot/AMPM2_MYCTU AMPM2_MYCTU]] Removes the N-terminal methionine from nascent proteins, when the penultimate amino acid is alanine or proline, but enzyme activity is remarkably low when the second residue is phenylalanine or leucine. With glycine at the second position, Map is more active with a tetrapeptide than with a tripeptide.<ref>PMID:19688379</ref> <ref>PMID:20038112</ref>
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Authors: Reddi, R., Gumpena, R., Kishor, C., Addlagatta, A.
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==About this Structure==
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[[4iec]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEC OCA].
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Description: Cys105 covalent modification by 2-hydroxyethyl disulfide in Mycobacterium tuberculosis methionine aminopeptidase Type 1c
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Methionyl aminopeptidase]]
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[[Category: Addlagatta, A.]]
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[[Category: Gumpena, R.]]
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[[Category: Kishor, C.]]
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[[Category: Reddi, R.]]
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[[Category: 2-hydroxyethyl disulfide]]
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[[Category: Cobalt]]
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[[Category: Hydrolase]]
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[[Category: Methionine aminopeptidase]]
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[[Category: Pita-bread fold]]

Revision as of 10:36, 18 December 2013

Template:STRUCTURE 4iec

Contents

Cys105 covalent modification by 2-hydroxyethyl disulfide in Mycobacterium tuberculosis methionine aminopeptidase Type 1c

Function

[AMPM2_MYCTU] Removes the N-terminal methionine from nascent proteins, when the penultimate amino acid is alanine or proline, but enzyme activity is remarkably low when the second residue is phenylalanine or leucine. With glycine at the second position, Map is more active with a tetrapeptide than with a tripeptide.[1] [2]

About this Structure

4iec is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Zhang X, Chen S, Hu Z, Zhang L, Wang H. Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv. Curr Microbiol. 2009 Nov;59(5):520-5. doi: 10.1007/s00284-009-9470-3. Epub 2009, Aug 18. PMID:19688379 doi:10.1007/s00284-009-9470-3
  2. ↑ Lu JP, Chai SC, Ye QZ. Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase. J Med Chem. 2009 Dec 28. PMID:20038112 doi:10.1021/jm901624n

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