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= Human C-reactive protein (CRP) =
= Human C-reactive protein (CRP) =
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The C-reactive protein (CRP) is a plasma protein, mainly synthesized by the liver. whose concentration increases in response to inflammation: It's an
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The C-reactive protein (CRP) is a plasma protein, mainly synthesized by the liver. Its concentration may increase rapidly,
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as much as 1000-fold or more, in response to tissue injury, infection and inflammation: It's an acute-phase protein.
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This important rise in amount after inflammatory stimulus suggests that CRP is a part of the innate immune response in the host defense.
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CRP is a pattern recognition molecule, binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens.
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== '''Structure of CRP''' ==
== '''Structure of CRP''' ==

Revision as of 15:44, 24 December 2013

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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Contents

Human C-reactive protein (CRP)

The C-reactive protein (CRP) is a plasma protein, mainly synthesized by the liver. Its concentration may increase rapidly, as much as 1000-fold or more, in response to tissue injury, infection and inflammation: It's an acute-phase protein. This important rise in amount after inflammatory stimulus suggests that CRP is a part of the innate immune response in the host defense. CRP is a pattern recognition molecule, binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens.


Structure of CRP

The Calcium and Phosphocholine binding sites

Interaction with C1q

Interaction with Fcγ receptors

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