4hdh

From Proteopedia

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m (Protected "4hdh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4hdh| PDB=4hdh | SCENE= }}
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===Crystal Structure of viral RdRp in complex with ATP===
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{{ABSTRACT_PUBMED_24293643}}
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The entry 4hdh is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/G3LHD9_9FLAV G3LHD9_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
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Authors: Surana, P., Nair, D.T.
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==About this Structure==
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[[4hdh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HDH OCA].
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Description: Crystal Structure of viral RdRp in complex with ATP
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==Reference==
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<ref group="xtra">PMID:024293643</ref><references group="xtra"/><references/>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Nair, D T.]]
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[[Category: Surana, P.]]
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[[Category: Dna/rna polymerase]]
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[[Category: Rna directed rna polymerase]]
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[[Category: Transferase]]

Revision as of 10:12, 25 December 2013

Template:STRUCTURE 4hdh

Contents

Crystal Structure of viral RdRp in complex with ATP

Template:ABSTRACT PUBMED 24293643

Function

[G3LHD9_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]

About this Structure

4hdh is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Surana P, Satchidanandam V, Nair DT. RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. Nucleic Acids Res. 2013 Nov 28. PMID:24293643 doi:http://dx.doi.org/10.1093/nar/gkt1106

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OCA

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