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4i8n

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4i8n| PDB=4i8n | SCENE= }}
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===CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID===
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{{ABSTRACT_PUBMED_23964742}}
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The entry 4i8n is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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Authors: Reddy, S.V.V., Rao, K.N., Subramanya, H.
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==About this Structure==
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[[4i8n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8N OCA].
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Description:
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==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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==Reference==
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<ref group="xtra">PMID:023964742</ref><references group="xtra"/><references/>
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[[Category: Human]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Rao, K N.]]
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[[Category: Reddy, S M.V V.V.]]
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[[Category: Subramanya, H.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protein phosphatase]]
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[[Category: Ptp1b]]

Revision as of 10:55, 1 January 2014

Template:STRUCTURE 4i8n

Contents

CRYSTAL STRUCTURE of PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN INHIBITOR [(4-{(2S)-2-(1,3-BENZOXAZOL-2-YL)-2-[(4-FLUOROPHENYL)SULFAMOYL]ETHYL}PHENYL)AMINO](OXO)ACETIC ACID

Template:ABSTRACT PUBMED 23964742

Function

[PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2]

About this Structure

4i8n is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

Reference

  • Reddy MV, Ghadiyaram C, Panigrahi SK, Krishnamurthy NR, Hosahalli S, Chandrasekharappa AP, Manna D, Badiger SE, Dubey PK, Mangamoori LN. X-Ray Structure of PTP1B in Complex with a New PTP1B Inhibitor. Protein Pept Lett. 2014;21(1):90-3. PMID:23964742
  1. ↑ Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010, Dec 6. PMID:21135139 doi:10.1083/jcb.201005035
  2. ↑ Krishnan N, Fu C, Pappin DJ, Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. PMID:22169477 doi:10.1126/scisignal.2002329

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