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2mio

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_2mio| PDB=2mio | SCENE= }}
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===Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A===
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The entry 2mio is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RHG10_HUMAN RHG10_HUMAN]] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
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Authors: Xu, X., Eletsky, A., Pulavarti, S.V.S.R.K., Wang, H., Janjua, H., Xiao, R., Everett, J.K., Sukumaran, D.T., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
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==About this Structure==
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[[2mio]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA].
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Description: Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A
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[[Category: Eletsky, A.]]
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[[Category: Everett, J K.]]
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[[Category: Janjua, H.]]
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[[Category: Montelione, G T.]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Pulavarti, S V.S R.K.]]
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[[Category: Sukumaran, D K.]]
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[[Category: Szyperski, T.]]
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[[Category: Wang, H.]]
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[[Category: Xiao, R.]]
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[[Category: Xu, X.]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]

Revision as of 12:11, 1 January 2014

Template:STRUCTURE 2mio

Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A

Function

[RHG10_HUMAN] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

About this Structure

2mio is a 1 chain structure. Full experimental information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mio"
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