Signal recognition particle receptor
From Proteopedia
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| - | <Structure load='2fh5' size='400' frame='true' align='right' caption='Human SRPR α (grey) and β subunit (green) complex with GTP and Mg+2 (green) ion [[2fh5]]' scene= /> | + | <Structure load='2fh5' size='400' frame='true' align='right' caption='Human SRPR α (grey) and β subunit (green) complex with GTP (stick model) and Mg+2 (green) ion [[2fh5]]' scene= /> |
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Revision as of 09:57, 2 January 2014
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Signal recognition particle receptor (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the signal recognition particle (SRP). SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called FtsY.
3D structures of SRPR
Updated on 02-January-2014
1nrj – ySRPR α+β subunits + GTP – yeast
2fh5 - hSRPR α+β subunits + GTP – human
2ged - ySRPR β subunit (mutant)
2go5 - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - EM
3dm9, 3dmd, 3e70 – SRPR + GDP – Pyrococcus furiosus
SRPR FtsY
1zu5, 1zu4 – SRPR FtsY NG domain – Mycoplasma mycoides
1vma – SRPR FtsY – Thermotoga maritima
2yhs, 2qy9, 1fts – EcSRPR FtsY NG domain – Escherichia coli
2q9a – EcSRPR FtsY
2q9c, 2q9b – EcSRPR FtsY NG domain + GMPPNP
2iyl – EcSRPR FtsY residues 20-303 + GDP
2xxa - EcSRPR FtsY NG domain + signal recognition particle protein residues 1-433 (mutant) + 4.5SRNA
3zn8 - EcSRPR FtsY NG domain + signal recognition particle protein 54 NG domain + 4.5SRNA + dipeptidyl aminopeptidase B
2j7p, 1rj9, 1okk – TaSRPR FtsY NG domain + signal recognition particle protein – Thermus aquaticus
2cnw – TaSRPR FtsY NG domain + signal recognition particle protein + GDP
