4bea
From Proteopedia
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{{STRUCTURE_4bea| PDB=4bea | SCENE= }} | {{STRUCTURE_4bea| PDB=4bea | SCENE= }} | ||
===Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative=== | ===Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative=== | ||
| + | {{ABSTRACT_PUBMED_24336354}} | ||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024336354</ref><references group="xtra"/><references/> |
[[Category: Brown, C J.]] | [[Category: Brown, C J.]] | ||
[[Category: Lama, D.]] | [[Category: Lama, D.]] | ||
Revision as of 08:21, 8 January 2014
Contents |
Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative
Template:ABSTRACT PUBMED 24336354
Function
[IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.[1]
About this Structure
4bea is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Lama D, Quah ST, Verma CS, Lakshminarayanan R, Beuerman RW, Lane DP, Brown CJ. Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces. Sci Rep. 2013 Dec 13;3:3451. doi: 10.1038/srep03451. PMID:24336354 doi:http://dx.doi.org/10.1038/srep03451
- ↑ Tomoo K, Matsushita Y, Fujisaki H, Abiko F, Shen X, Taniguchi T, Miyagawa H, Kitamura K, Miura K, Ishida T. Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. Biochim Biophys Acta. 2005 Dec 1;1753(2):191-208. Epub 2005 Aug 24. PMID:16271312 doi:10.1016/j.bbapap.2005.07.023
