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3hj3

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{{STRUCTURE_3hj3| PDB=3hj3 | SCENE= }}
{{STRUCTURE_3hj3| PDB=3hj3 | SCENE= }}
===Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant===
===Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant===
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{{ABSTRACT_PUBMED_24324854}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[3hj3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJ3 OCA].
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[[3hj3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryho Cryho]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJ3 OCA].
==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase|Thymidylate synthase]]
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[[Category: Cryptosporidium hominis]]
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==Reference==
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<ref group="xtra">PMID:024324854</ref><references group="xtra"/><references/>
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[[Category: Cryho]]
[[Category: Anderson, K S.]]
[[Category: Anderson, K S.]]
[[Category: Martucci, W E.]]
[[Category: Martucci, W E.]]

Revision as of 06:44, 15 January 2014

Template:STRUCTURE 3hj3

Contents

Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant

Template:ABSTRACT PUBMED 24324854

Function

[Q5CGA3_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

3hj3 is a 4 chain structure with sequence from Cryho. Full crystallographic information is available from OCA.

See Also

Reference

  • Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: alpha-helix mimetics targeting a key allosteric protein-protein interaction in TS-DHFR. Medchemcomm. 2013 Sep;4(9). doi: 10.1039/C3MD00141E. PMID:24324854 doi:http://dx.doi.org/10.1039/C3MD00141E

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