This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3pz3
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3pz3.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3pz3", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3pz3| PDB=3pz3 | SCENE= }} | {{STRUCTURE_3pz3| PDB=3pz3 | SCENE= }} | ||
| - | |||
===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14=== | ===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3pz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3pz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ3 OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021520375</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Protein geranylgeranyltransferase type II]] | [[Category: Protein geranylgeranyltransferase type II]] | ||
[[Category: Alexandrov, K.]] | [[Category: Alexandrov, K.]] | ||
Revision as of 06:44, 15 January 2014
Contents |
Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14
Function
[PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [PGTB2_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
About this Structure
3pz3 is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
Reference
- Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H. Structure-Guided Development of Selective RabGGTase Inhibitors. Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi:, 10.1002/anie.201101210. Epub 2011 Apr 21. PMID:21520375 doi:10.1002/anie.201101210
