2cca

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[[Image:2cca.png|left|200px]]
 
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{{STRUCTURE_2cca| PDB=2cca | SCENE= }}
{{STRUCTURE_2cca| PDB=2cca | SCENE= }}
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===Crystal structure of the catalase-peroxidase (KatG) and S315T mutant from Mycobacterium tuberculosis===
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{{ABSTRACT_PUBMED_16566587}}
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===CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) AND S315T MUTANT FROM MYCOBACTERIUM TUBERCULOSIS===
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==Function==
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[[http://www.uniprot.org/uniprot/KATG_MYCTU KATG_MYCTU]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.<ref>PMID:10463167</ref>
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{{ABSTRACT_PUBMED_16566587}}
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==About this Structure==
==About this Structure==
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[[2cca]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCA OCA].
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[[2cca]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCA OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016566587</ref><ref group="xtra">PMID:018956888</ref><references group="xtra"/>
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<ref group="xtra">PMID:016566587</ref><references group="xtra"/><references/>
[[Category: Catalase]]
[[Category: Catalase]]
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[[Category: Mycobacterium tuberculosis]]
 
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]
[[Category: Yu, H.]]
[[Category: Yu, H.]]

Revision as of 06:45, 15 January 2014

Template:STRUCTURE 2cca

Contents

Crystal structure of the catalase-peroxidase (KatG) and S315T mutant from Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 16566587

Function

[KATG_MYCTU] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.[1]

About this Structure

2cca is a 2 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.

See Also

Reference

  • Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS. Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant. Biochemistry. 2006 Apr 4;45(13):4131-40. PMID:16566587 doi:10.1021/bi051967o
  1. ↑ Mulder MA, Nair S, Abratt VR, Zappe H, Steyn LM. Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents. Microbiology. 1999 Aug;145 ( Pt 8):2011-21. PMID:10463167

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