This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2yab
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2yab.png|left|200px]] | ||
| - | |||
{{STRUCTURE_2yab| PDB=2yab | SCENE= }} | {{STRUCTURE_2yab| PDB=2yab | SCENE= }} | ||
| + | ===Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP=== | ||
| + | {{ABSTRACT_PUBMED_21497605}} | ||
| - | === | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/DAPK2_MOUSE DAPK2_MOUSE]] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4] | |
| - | + | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[2yab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAB OCA]. |
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021497605</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021497605</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Kursula, P.]] | [[Category: Kursula, P.]] | ||
Revision as of 07:01, 15 January 2014
Contents |
Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP
Template:ABSTRACT PUBMED 21497605
Function
[DAPK2_MOUSE] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
About this Structure
2yab is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See Also
Reference
- Patel AK, Yadav RP, Majava V, Kursula I, Kursula P. Structure of the Dimeric Autoinhibited Conformation of DAPK2, a Pro-Apoptotic Protein Kinase. J Mol Biol. 2011 Apr 8. PMID:21497605 doi:10.1016/j.jmb.2011.03.065
