4mju

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'''Unreleased structure'''
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{{STRUCTURE_4mju| PDB=4mju | SCENE= }}
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===Influenza Neuraminidase in complex with a novel antiviral compound===
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{{ABSTRACT_PUBMED_24339250}}
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The entry 4mju is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NRAM_I63A3 NRAM_I63A3]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
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Authors: Kerry, P.S.
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==About this Structure==
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[[4mju]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJU OCA].
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Description: Influenza Neuraminidase in complex with a novel antiviral compound
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==Reference==
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<ref group="xtra">PMID:024339250</ref><references group="xtra"/><references/>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Influenza a virus]]
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[[Category: Kerry, P S.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Neuraminidase]]
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[[Category: Sialidase]]
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[[Category: Viral protein]]

Revision as of 08:15, 15 January 2014

Template:STRUCTURE 4mju

Contents

Influenza Neuraminidase in complex with a novel antiviral compound

Template:ABSTRACT PUBMED 24339250

Function

[NRAM_I63A3] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.

About this Structure

4mju is a 1 chain structure with sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

  • Mohan S, Kerry PS, Bance N, Niikura M, Pinto BM. Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor. Angew Chem Int Ed Engl. 2013 Dec 11. doi: 10.1002/anie.201308142. PMID:24339250 doi:http://dx.doi.org/10.1002/anie.201308142

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