4lbl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4lbl| PDB=4lbl | SCENE= }}
 +
===Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3===
 +
{{ABSTRACT_PUBMED_24326249}}
-
The entry 4lbl is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
-
Authors: Bum-Erdene, K., Blanchard, H.
+
==About this Structure==
 +
[[4lbl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LBL OCA].
-
Description: Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3
+
==Reference==
 +
<ref group="xtra">PMID:024326249</ref><references group="xtra"/><references/>
 +
[[Category: Blanchard, H.]]
 +
[[Category: Bum-Erdene, K.]]
 +
[[Category: Beta sandwich]]
 +
[[Category: Carbohydrate binding protein]]
 +
[[Category: Carbohydrate-recognition]]
 +
[[Category: Galectin]]
 +
[[Category: Glycosphingolipid]]
 +
[[Category: Gm3]]
 +
[[Category: Sugar binding protein]]

Revision as of 06:57, 22 January 2014

Template:STRUCTURE 4lbl

Contents

Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3

Template:ABSTRACT PUBMED 24326249

Function

[LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.[1] [2] [3]

About this Structure

4lbl is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Fukushi J, Makagiansar IT, Stallcup WB. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell. 2004 Aug;15(8):3580-90. Epub 2004 Jun 4. PMID:15181153 doi:http://dx.doi.org/10.1091/mbc.E04-03-0236
  2. ↑ Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009 Jul;230(1):160-71. doi: 10.1111/j.1600-065X.2009.00794.x. PMID:19594635 doi:10.1111/j.1600-065X.2009.00794.x
  3. ↑ Haudek KC, Spronk KJ, Voss PG, Patterson RJ, Wang JL, Arnoys EJ. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta. 2010 Feb;1800(2):181-189. Epub 2009 Jul 16. PMID:19616076 doi:S0304-4165(09)00194-9

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lbl"
Personal tools