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4by0

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'''Unreleased structure'''
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{{STRUCTURE_4by0| PDB=4by0 | SCENE= }}
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===Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide===
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The entry 4by0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512]
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Authors: Choi, J.Y., Calvet, C.M., Gunatilleke, S.S., Li, L., Cameron, M.D., Roush, W.R., McKerrow, J.H., Podust, L.M.
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==About this Structure==
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[[4by0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BY0 OCA].
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Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor ( R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'-difluoro-(1,1'-biphenyl)-4-carboxamide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Sterol 14-demethylase]]
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[[Category: Calvet, C M.]]
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[[Category: Cameron, M D.]]
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[[Category: Choi, J Y.]]
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[[Category: Gunatilleke, S S.]]
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[[Category: McKerrow, J H.]]
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[[Category: Podust, L M.]]
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[[Category: Roush, W R.]]
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[[Category: Vierira, D F.]]
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[[Category: Chagas disease]]
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[[Category: Oxidoreductase]]
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[[Category: Sterol 14-demethylase]]
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[[Category: Sterol biosynthesis]]

Revision as of 07:00, 22 January 2014

Template:STRUCTURE 4by0

Contents

Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide

Function

[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1] [UniProtKB:P0A512]

About this Structure

4by0 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200

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