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4f3f

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[[Image:4f3f.jpg|left|200px]]
 
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{{STRUCTURE_4f3f| PDB=4f3f | SCENE= }}
{{STRUCTURE_4f3f| PDB=4f3f | SCENE= }}
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===Crystal Structure of Msln7-64 MORAb-009 FAB complex===
===Crystal Structure of Msln7-64 MORAb-009 FAB complex===
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==Disease==
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[[http://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN]] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
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==Function==
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[[http://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN]] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref>
==About this Structure==
==About this Structure==
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[[4f3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3F OCA].
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[[4f3f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3F OCA].
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Human]]
[[Category: Esser, L.]]
[[Category: Esser, L.]]
[[Category: Ma, J.]]
[[Category: Ma, J.]]

Revision as of 09:14, 5 February 2014

Template:STRUCTURE 4f3f

Contents

Crystal Structure of Msln7-64 MORAb-009 FAB complex

Disease

[MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.

Function

[MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.[1] [2] Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.[3] [4]

About this Structure

4f3f is a 3 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895 and Human. Full crystallographic information is available from OCA.

Reference

  1. ↑ Yamaguchi N, Hattori K, Oh-eda M, Kojima T, Imai N, Ochi N. A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. J Biol Chem. 1994 Jan 14;269(2):805-8. PMID:8288629
  2. ↑ Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Miyajima A. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem. 2004 Mar 5;279(10):9190-8. Epub 2003 Dec 15. PMID:14676194 doi:http://dx.doi.org/10.1074/jbc.M312372200
  3. ↑ Yamaguchi N, Hattori K, Oh-eda M, Kojima T, Imai N, Ochi N. A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. J Biol Chem. 1994 Jan 14;269(2):805-8. PMID:8288629
  4. ↑ Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, Miyajima A. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem. 2004 Mar 5;279(10):9190-8. Epub 2003 Dec 15. PMID:14676194 doi:http://dx.doi.org/10.1074/jbc.M312372200

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