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4o6a
From Proteopedia
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| - | + | {{STRUCTURE_4o6a| PDB=4o6a | SCENE= }} | |
| + | ===Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | ||
| - | + | ==About this Structure== | |
| - | + | [[4o6a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6A OCA]. | |
| - | + | [[Category: Cyclic GMP-AMP synthase]] | |
| + | [[Category: Chen, Z.]] | ||
| + | [[Category: Chen, Z J.]] | ||
| + | [[Category: Zhang, X.]] | ||
| + | [[Category: Zhang, X W.]] | ||
| + | [[Category: Immune response]] | ||
| + | [[Category: Transferase-dna complex]] | ||
Revision as of 11:38, 5 February 2014
Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4o6a is a 6 chain structure. Full crystallographic information is available from OCA.
