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4l70
From Proteopedia
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| - | + | {{STRUCTURE_4l70| PDB=4l70 | SCENE= }} | |
| + | ===Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352=== | ||
| + | {{ABSTRACT_PUBMED_24188023}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4l70]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L70 OCA]. | ||
| - | + | ==Reference== | |
| + | <ref group="xtra">PMID:024188023</ref><references group="xtra"/><references/> | ||
| + | [[Category: Andersson, C D.]] | ||
| + | [[Category: Ekblad, T.]] | ||
| + | [[Category: Elofsson, M.]] | ||
| + | [[Category: Karlberg, T.]] | ||
| + | [[Category: Lindgren, A E.G.]] | ||
| + | [[Category: Linusson, A.]] | ||
| + | [[Category: Schuler, H.]] | ||
| + | [[Category: Spjut, S.]] | ||
| + | [[Category: Thorsell, A G.]] | ||
| + | [[Category: Weigelt, J.]] | ||
| + | [[Category: Adp-ribosylation]] | ||
| + | [[Category: Diphtheria toxin like adp-ribose transferase]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 17:33, 19 February 2014
Contents |
Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352
Template:ABSTRACT PUBMED 24188023
Function
[PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.[1]
About this Structure
4l70 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A, Schuler H, Elofsson M. Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68. doi: 10.1021/jm401394u. Epub 2013 Nov 22. PMID:24188023 doi:http://dx.doi.org/10.1021/jm401394u
- ↑ Rouleau M, McDonald D, Gagne P, Ouellet ME, Droit A, Hunter JM, Dutertre S, Prigent C, Hendzel MJ, Poirier GG. PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. J Cell Biochem. 2007 Feb 1;100(2):385-401. PMID:16924674 doi:10.1002/jcb.21051
