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4niy

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4niy| PDB=4niy | SCENE= }}
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===Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)===
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{{ABSTRACT_PUBMED_24520050}}
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The entry 4niy is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ECOT_ECOLI ECOT_ECOLI]] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]
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Authors: Schoepfel, M., Parthier, C., Stubbs, M.T.
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==About this Structure==
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[[4niy]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIY OCA].
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Description: Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)
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==Reference==
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<ref group="xtra">PMID:024520050</ref><references group="xtra"/><references/>
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[[Category: Trypsin]]
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[[Category: Parthier, C.]]
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[[Category: Schoepfel, M.]]
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[[Category: Stubbs, M T.]]
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[[Category: Activation domain]]
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[[Category: Enzyme design]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Peptide ligation]]
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[[Category: Reverse proteolysis]]
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[[Category: Serine proteinase]]
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[[Category: Trypsin inhibitor]]

Revision as of 17:36, 19 February 2014

Template:STRUCTURE 4niy

Contents

Crystal structure of trypsiligase (K60E/N143H/Y151H/D189K trypsin) complexed to YRH-ecotin (M84Y/M85R/A86H ecotin)

Template:ABSTRACT PUBMED 24520050

Function

[ECOT_ECOLI] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706]

About this Structure

4niy is a 8 chain structure. Full crystallographic information is available from OCA.

Reference

  • Liebscher S, Schopfel M, Aumuller T, Sharkhuukhen A, Pech A, Hoss E, Parthier C, Jahreis G, Stubbs MT, Bordusa F. N-Terminal Protein Modification by Substrate-Activated Reverse Proteolysis. Angew Chem Int Ed Engl. 2014 Feb 12. doi: 10.1002/anie.201307736. PMID:24520050 doi:http://dx.doi.org/10.1002/anie.201307736

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OCA

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