Deaminase
From Proteopedia
(Difference between revisions)
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<StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''> | <StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''> | ||
| - | '''Deaminase''' removes an amine group from a molecule. '''Cytosine deaminase''' ( | + | '''Deaminase''' removes an amine group from a molecule. '''Cytosine deaminase''' (CDDA) converts cytosine to uracil. '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. 5-methylcytosine deaminase (MCDA) produces thymine. '''Guanine deaminase''' (GDA) converts guanine to xanthine. '''Adenine deaminase''' (ADA) converts adenine to hypoxanthine. |
| - | 5-methylcytosine deaminase (MCDA) produces thymine. '''Guanine deaminase''' (GDA) converts guanine to xanthine. '''Adenine deaminase''' (ADA) converts adenine to hypoxanthine. | + | |
== 3D Structures of deaminase == | == 3D Structures of deaminase == | ||
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'''Cytidine deaminase''' | '''Cytidine deaminase''' | ||
| - | [[1r5t]] – | + | [[1r5t]] – yCDA - yeast <BR /> |
[[2a8n]] – AtCDA – ''Agrobacterium tumefaciens'' <BR /> | [[2a8n]] – AtCDA – ''Agrobacterium tumefaciens'' <BR /> | ||
[[2g84]] – CDA – ''Nitrosomonas europaea'' <BR /> | [[2g84]] – CDA – ''Nitrosomonas europaea'' <BR /> | ||
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[[2fr6]] – mCDA + cytidine + uridine <BR /> | [[2fr6]] – mCDA + cytidine + uridine <BR /> | ||
[[4eg2]] – CDA + uridine - ''Vibrio cholerae'' <BR /> | [[4eg2]] – CDA + uridine - ''Vibrio cholerae'' <BR /> | ||
| + | |||
| + | '''Cytosine deaminase''' | ||
| + | |||
| + | [[1k6w]] – EcCDDA <BR /> | ||
| + | [[1r9x]], [[1r9y]], [[1r9z]], [[1ra0]], [[1ra5]], [[3g77]] – EcCDDA (mutant)<BR /> | ||
| + | [[1rb7]], [[1uaq]] – yCDDA <BR /> | ||
| + | [[1ysb]], [[1ysd]] – yCDDA (mutant)<BR /> | ||
| + | |||
| + | ''Cytosine deaminase complex'' | ||
| + | |||
| + | [[3r0d]] – EcCDDA + Zn <BR /> | ||
| + | [[3rn6]] – EcCDDA + Zn + iso-guanine<BR /> | ||
| + | [[1k70]] – EcCDDA + pyrimidine derivative<BR /> | ||
| + | [[1rak]] – EcCDDA (mutant) + pyrimidine derivative<BR /> | ||
| + | [[3o7u]] – EcCDDA + Zn + phosphono-cytosine<BR /> | ||
| + | [[1ox7]] – yCDDA + Zn <BR /> | ||
| + | [[1p6o]] – yCDDA + pyrimidine derivative<BR /> | ||
| + | [[2o3k]] – yCDDA (mutant) + pyrimidine derivative<BR /> | ||
'''Guanine deaminase''' | '''Guanine deaminase''' | ||
[[1tiy]], [[1wkq]] – BsGDA <BR /> | [[1tiy]], [[1wkq]] – BsGDA <BR /> | ||
| + | [[3e0l]] – hGDA<br /> | ||
''Guanine deaminase complex with nucleoside'' | ''Guanine deaminase complex with nucleoside'' | ||
Revision as of 10:53, 24 February 2014
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