Defensin

From Proteopedia

Revision as of 11:44, 24 February 2014

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Defensins (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients. There is increase in α-DEF in chronic inflammations and several cancers. For details on plant DEF see Plant defensin.

3D structures of defensin

α-defensin

1ica – DEFA – Protophormia terraenovae
1ews – DEFA RK-1 – rabbit – NMR
2k1i - RmDEFA – Rhesus macaque - NMR
1zmh, 1zmi, 1zmk - hDEFA HNP-2 (mutant) – human
3gny, 3go0, 3hj2 - hDEFA HNP-1
2kht - hDEFA HNP-1 - NMR
2pm1, 2pm4, 2pm5, 3hjd, 3h6c, 3lo1, 3lo2, 3lo4, 3lo6, 3lo8, 3loe, 3lvx, 4du0, 4lb1, 4lb7, 4lbb, 4lbf - hDEFA HNP-1 (mutant)
1zmm – hDEFA4
2lew – mDEFA4 (mutant) – mouse – NMR
2ley – mDEFA4 – NMR
1zmp – hDEFA5
2lxz – hDEFA5 – NMR
3i5w, 4e82, 4e83, 4e86 – hDEFA5 (mutant)
1zmq – hDEFA6
3qte – hDEFA6 (mutant)

β-defensin

1iju, 1ijv – hDEFB1
2nlb, 2nld, 2nle, 2nlf, 2nlg, 2nlh, 2nlp, 2nlq, 2nls, 2plz, 2lwl, 2nlc - hDEFB1 (mutant)
1e4s, 1kj5 – hDEFB1 – NMR
1fd3, 1fd4 – hDEFB2
1fqq, 1e4q - hDEFB2 – NMR
2lg5 - cDEFB2 – chicken – NMR
2lg6 - cDEFB2 (mutant) – NMR
1kj6 – hDEFB3 – NMR
1e4t – mDEFB7 – NMR
1e4r - mDEFB8 – NMR
1bnb – DEFB12 – bovine – NMR

ϑ-defensin

1hvz – RmDEF1 – NMR

Other defensins

1dfn – hDEF HNP-3
1fjn – DEF MGD-1 – Mediterranean mussel
1mr4 – tDEF NAD1 – tobacco – NMR
4aaz, 4ab0 - tDEF NAD1
1ozz – AdDEF ARD1 – Archaeoprepona demophon – NMR
1p00, 1p0a - AdDEF ARD1 (mutant) – NMR
1ti5 - VrDEF – Vigna radiata – NMR
2gl1 – VrDEF2
2b68 - DEF – Pacific oyster – NMR
2b5b - DEF – Loggerhead turtle – NMR
2e3e, 2e3f, 2e3g, 2ny8, 2ny9, 2nz3 - DEF (mutant) – Anopheles – NMR
2rng - DEF – Horseshoe crab – NMR
3psm – DEF – Potato bean
2ksk – DEF5 – Sugarcane - NMR
2lj7 – DEF – lentil – NMR
2lr3 – DEF – barrel medic – NMR