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2bq4
From Proteopedia
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Revision as of 14:40, 30 October 2007
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CRYSTAL STRUCTURE OF TYPE I CYTOCHROME C3 FROM DESULFOVIBRIO AFRICANUS
Overview
In Desulfovibrio metabolism, periplasmic hydrogen oxidation is coupled to, cytoplasmic sulfate reduction via transmembrane electron transfer, complexes. Type II tetraheme cytochrome c3 (TpII-c3), nine-heme cytochrome, c (9HcA) and 16-heme cytochrome c (HmcA) are periplasmic proteins, associated to these membrane-bound redox complexes and exhibit analogous, physiological function. Type I tetraheme cytochrome c3 (TpI-c3) is thought, to act as a mediator for electron transfer from hydrogenase to these, multihemic cytochromes. In the present work we have investigated, Desulfovibrio africanus (Da) and Desulfovibrio vulgaris Hildenborough, (DvH) TpI-c3/TpII-c3 complexes. Comparative kinetic experiments of Da, TpI-c3 and TpII-c3 using electrochemistry confirm that TpI-c3 is much more, efficient ... [(full description)]
About this Structure
2BQ4 is a [Single protein] structure of sequence from [Desulfovibrio africanus] with CA and HEC as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The type I/type II cytochrome c3 complex: an electron transfer link in the hydrogen-sulfate reduction pathway., Pieulle L, Morelli X, Gallice P, Lojou E, Barbier P, Czjzek M, Bianco P, Guerlesquin F, Hatchikian EC, J Mol Biol. 2005 Nov 18;354(1):73-90. Epub 2005 Sep 29. PMID:16226767
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