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4lzj

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'''Unreleased structure'''
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{{STRUCTURE_4lzj| PDB=4lzj | SCENE= }}
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===Crystal Structure of MurQ from H.influenzae with bound inhibitor===
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{{ABSTRACT_PUBMED_24251551}}
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The entry 4lzj is ON HOLD until sometime in the future
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==Function==
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[[http://www.uniprot.org/uniprot/MURQ_HAEIN MURQ_HAEIN]] Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity).
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Authors: Hazra, S., Blanchard, J.
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==About this Structure==
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[[4lzj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LZJ OCA].
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Description: Crystal Structure of MurQ from H.influenzae with bound inhibitor
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==Reference==
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<ref group="xtra">PMID:024251551</ref><references group="xtra"/><references/>
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[[Category: N-acetylmuramic acid 6-phosphate etherase]]
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[[Category: Blanchard, J.]]
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[[Category: Hazra, S.]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: D-muramitol 6-phosphate]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Murq]]
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[[Category: Protein-ligand complex]]
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[[Category: Yfeu]]

Revision as of 17:58, 3 March 2014

Template:STRUCTURE 4lzj

Contents

Crystal Structure of MurQ from H.influenzae with bound inhibitor

Template:ABSTRACT PUBMED 24251551

Function

[MURQ_HAEIN] Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity).

About this Structure

4lzj is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Hadi T, Hazra S, Tanner ME, Blanchard JS. Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor. Biochemistry. 2013 Dec 23;52(51):9358-66. doi: 10.1021/bi4010446. Epub 2013 Nov, 22. PMID:24251551 doi:http://dx.doi.org/10.1021/bi4010446

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