Factor inhibiting HIF
From Proteopedia
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[[2cgo]] – hFIH1α + fumarate<br /> | [[2cgo]] – hFIH1α + fumarate<br /> | ||
[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br /> | [[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br /> | ||
| - | [[3kcx]], [[3kcy]], [[3od4]] - hFIH1α + quinol derivative<br /> | + | [[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br /> |
| + | [[4ai8]] - hFIH1α + daminozide<br /> | ||
===FIH1α complex with polypeptide=== | ===FIH1α complex with polypeptide=== | ||
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[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br /> | [[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br /> | ||
[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br /> | [[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br /> | ||
| + | [[4b7e]], [[4b7k]], [[4jaa]] - hFIH1α + consensus ankyrin repeat peptide<br /> | ||
===FIH2α=== | ===FIH2α=== | ||
Revision as of 11:37, 4 March 2014
For details on Factor inhibiting HIF see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.
Contents |
3D Structures of factor inhibiting HIF
Updated on 04-March-2014
1mze, 1h2n, 1iz3 – hFIH1α – human
FIH1α complex with small molecule
1yci, 3od4, 2yc0, 2yde– hFIH1α + inhibitor
2w0x - hFIH1α + pyridine derivative
2cgn – hFIH1α + succinate
2cgo – hFIH1α + fumarate
1mzf, 2wa3, 2wa4, 2yc0, 2yde – hFIH1α + oxoglutarate derivative
3kcx, 3kcy, 3od4, 4bio - hFIH1α + quinol derivative
4ai8 - hFIH1α + daminozide
FIH1α complex with polypeptide
1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
2ilm, 3d8c - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
3p3n, 3p3p - hFIH1α + Notch 1 peptide
2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
2y0i - hFIH1α + tankyrase 2 peptide
3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
4h6j - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator
4b7e, 4b7k, 4jaa - hFIH1α + consensus ankyrin repeat peptide
FIH2α
2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
FIH1β
2b02, 1x0o - hFIH 1β PAS domain
2hv1, 2k7s - hFIH 1β PAS domain - NMR
