Glutamate dehydrogenase
From Proteopedia
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[[3k8z]], [[3k92]] – GLDH (mutant) – ''Bacillus subtilis''<br /> | [[3k8z]], [[3k92]] – GLDH (mutant) – ''Bacillus subtilis''<br /> | ||
[[2yfq]] - bGLDH – ''Peptoniphilus asaccharolyticus''<br /> | [[2yfq]] - bGLDH – ''Peptoniphilus asaccharolyticus''<br /> | ||
| - | [[3sbo]], [[2yfg]] - EcGLDH – ''Escherichia coli''<br /> | + | [[3sbo]], [[2yfg]], [[4bht]], [[4fcc]] - EcGLDH – ''Escherichia coli''<br /> |
[[2yfh]] – EcGLDH/CsGLDH | [[2yfh]] – EcGLDH/CsGLDH | ||
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[[3ete]], [[3etg]] - bGLDH + NADP + GTP + inhibitor + glutamate <br /> | [[3ete]], [[3etg]] - bGLDH + NADP + GTP + inhibitor + glutamate <br /> | ||
[[1nqt]] - bGLDH + ADP<br /> | [[1nqt]] - bGLDH + ADP<br /> | ||
| - | [[ | + | [[3qmu]] - bGLDH + NADP + epicatechin-e-gallate<br /> |
[[1bgv]] – CsGLDH + glutamate <br /> | [[1bgv]] – CsGLDH + glutamate <br /> | ||
[[1v9l]] - GLDH + NAD – ''Pyrobaculum islandicum''<br /> | [[1v9l]] - GLDH + NAD – ''Pyrobaculum islandicum''<br /> | ||
[[3aoe]] - TtGLDH + leucine – ''Thermus thermophilus''<br /> | [[3aoe]] - TtGLDH + leucine – ''Thermus thermophilus''<br /> | ||
[[3aog]] - TtGLDH + NH4 + glutamate <br /> | [[3aog]] - TtGLDH + NH4 + glutamate <br /> | ||
| + | [[4fhn]] – EcGLDH + Nup37 + Nup120<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:22, 11 March 2014
Template:STRUCTURE 1gtm Glutamate dehydrogenase (GLDH) catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonium. The ammonia is removed via the urea cycle. Elevated GLDH values in blood serum indicate liver malfunction. NAD or NADP is a cofactor in GLDH activity. NAD is a cofactor in the forward reaction while NADP is a cofactor in the reverse. GLDH is regulated by the cell’s energy state. ATP and GTP inhibit the enzyme while ADP, GDP and leucine positively enhance it. Glutamate dehydrogenase 1 (GLDH1) catalyzes the deamination of glutamate to 2-oxoglutarate and ammonium. GLDH1 is regulated in the same manner as GLDH.
3D structures of glutamate dehydrogenase
Updated on 11-March-2014
1gtm – GLDH – Pyrococcus furiosus
1hrd – CsGLDH – Clostridium symbiosum
1aup, 1k89 – CsGLDH (mutant)
1bvu – GLDH – Thermococcus litoralis
1euz - GLDH – Thermococcus profundus
1b26 – TmGLDH – Thermotoga maritima
1b3b, 2tmg - TmGLDH (mutant)
1l1f – hGLDH1 – human
1nr1 – hGLDH1 (mutant)
1nr7 – bGLDH – bovine
3mvo, 3mvq – bGLDH1
2bma – PfGLDH – Plasmodium falciparum
3r3j - PfGLDH (mutant)
3k8z, 3k92 – GLDH (mutant) – Bacillus subtilis
2yfq - bGLDH – Peptoniphilus asaccharolyticus
3sbo, 2yfg, 4bht, 4fcc - EcGLDH – Escherichia coli
2yfh – EcGLDH/CsGLDH
Glutamate dehydrogenase complex
1hwy – bGLDH + NAD + 2-oxoglutarate
1hwz – bGLDH + NADP + GTP + glutamate
3mw9 - bGLDH + NAD + GTP + glutamate
3ete, 3etg - bGLDH + NADP + GTP + inhibitor + glutamate
1nqt - bGLDH + ADP
3qmu - bGLDH + NADP + epicatechin-e-gallate
1bgv – CsGLDH + glutamate
1v9l - GLDH + NAD – Pyrobaculum islandicum
3aoe - TtGLDH + leucine – Thermus thermophilus
3aog - TtGLDH + NH4 + glutamate
4fhn – EcGLDH + Nup37 + Nup120
