EPSP synthase

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<StructureSection load='1eps' size='350' side='right' caption='Structure of EPSP synthase (PDB entry [[1eps]])' scene=''>
<StructureSection load='1eps' size='350' side='right' caption='Structure of EPSP synthase (PDB entry [[1eps]])' scene=''>
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5-enolpyruvylshikimate 3-phosphate (EPSP) synthase is a key enzyme for the biosynthesis of aromatic amino acids in plants and many microbes. Consequently, it is a target for drugs and herbicides. EPSP synthase catalyzes the addition of phosphoenol pyruvate (PEP) to shikimate-3-phosphate, generating 5-enolpyruvylshikimate-3-phosphate, which is a precursor for phenylalanine and tyrosine.
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'''5-enolpyruvylshikimate 3-phosphate (EPSP) synthase''' is a key enzyme for the biosynthesis of aromatic amino acids in plants and many microbes. Consequently, it is a target for drugs and herbicides. EPSP synthase catalyzes the addition of phosphoenol pyruvate (PEP) to shikimate-3-phosphate, generating 5-enolpyruvylshikimate-3-phosphate, which is a precursor for phenylalanine and tyrosine.
The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate.
The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate.
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===3D structures of EPSP synthase ===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1eps]] – EcEPSP – ''Escherichia coli''<br />
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[[1p88]], [[1p89]] - EcEPSP N terminal - NMR<br />
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[[1rf5]] - SpEPSP – ''Streptococcus pneumoniae''<br />
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[[2bjb]], [[2o15]] – MtEPSP – ''Mycobacterium tuberculosis''<br />
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[[2gg4]] – AgEPSP – ''Agrobacterium''<br />
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[[3roi]], [[3tr1]], [[4gfp]] – CbEPSP – ''Coxiella burnetii''<br />
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[[3ti2]] - VcEPSP N terminal – ''Vibrio cholerae''<br />
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===EPSP synthase binary complex===
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[[1g6t]] - EcEPSP + S3P <br />
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[[1mi4]], [[2qfq]], [[2qfs]], [[3fjx]], [[3fk0]] - EcEPSP (mutant) + S3P <br />
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[[1q36]] - EcEPSP (mutant) + S3P derivative<br />
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[[1x8r]], [[1x8t]] - EcEPSP + intermediate <br />
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[[2aa9]] – EcEPSP + shikimate<br />
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[[2pq9]] - EcEPSP + intermediate <br />
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[[1rf4]] - SpEPSP + intermediate <br />
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[[2o0b]], [[2o0d]] - MtEPSP + S3P <br />
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[[2gg6]] - AgEPSP + S3P <br />
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[[2pqb]], [[2pqc]], [[2pqd]] - AgEPSP + intermediate <br />
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[[2o0x]] - MtEPSP + intermediate <br />
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[[2o0z]] - MtEPSP + EPS <br />
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[[4egr]] - CbEPSP + phosphoenolpyruvate<br />
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===EPSP synthase ternary complex===
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[[1g6p]] - EcEPSP + S3P + glyphosate<br />
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[[2qft]], [[2qfu]], [[3fjz]], [[3fk1]] - EcEPSP (mutant) + S3P + glyphosate<br />
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[[2aay]] - EcEPSP + shikimate + glyphosate<br />
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[[1rf6]] - SpEPSP + S3P + glyphosate<br />
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[[2gga]] - AgEPSP + S3P + glyphosate<br />
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[[4ggd]] - AgEPSP (mutant) + S3P + glyphosate<br />
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[[2o0e]] - MtEPSP + S3P + phosphoenolpyruvate<br />
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[[3nvs]] - VcEPSP + S3P + glyphosate <br />
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[[3slh]] - CbEPSP + S3P + glyphosate<br />
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</StructureSection>
</StructureSection>
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[[Category:Topic Page]]

Revision as of 09:55, 12 March 2014

Structure of EPSP Synthase

Structure of EPSP synthase (PDB entry 1eps)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Ann Taylor, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/EPSP_synthase"
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