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4msu

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4msu| PDB=4msu | SCENE= }}
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===Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate===
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{{ABSTRACT_PUBMED_24405172}}
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The entry 4msu is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.
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Authors: Ashton, K.S., Andrews, K.L., Bryan, M.C., Chen, J., Chen, K., Chen, M., Chmait, S., Croghan, M., Cupples, R., Fotsch, C., Helmering, J., Jordan, S.R., Kurzeja, R.J., Michelsen, K., Pennington, L.D., Poon, S.F., Sivits, G., Van, G., Vonderfecht, S.L., Wahl, R.C., Zhang, J., Lloyd, D.J., Hale, C., St. Jean, D.J.
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==About this Structure==
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[[4msu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSU OCA].
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Description: Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate
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==Reference==
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<ref group="xtra">PMID:024405172</ref><references group="xtra"/><references/>
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[[Category: Andrews, K L.]]
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[[Category: Ashton, K S.]]
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[[Category: Bryan, M C.]]
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[[Category: Chen, J.]]
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[[Category: Chen, K.]]
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[[Category: Chen, M.]]
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[[Category: Chmait, S.]]
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[[Category: Croghan, M.]]
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[[Category: Cupples, R.]]
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[[Category: Fotsch, C.]]
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[[Category: Hale, C.]]
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[[Category: Helmering, J.]]
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[[Category: Jean, D J.St.]]
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[[Category: Jordan, S R.]]
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[[Category: Kurzeja, R J.]]
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[[Category: Lloyd, D J.]]
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[[Category: Michelsen, K.]]
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[[Category: Pennington, L D.]]
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[[Category: Poon, S F.]]
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[[Category: Sivits, G.]]
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[[Category: Van, G.]]
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[[Category: Vonderfecht, S L.]]
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[[Category: Wahl, R C.]]
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[[Category: Zhang, J.]]
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[[Category: Glucokinase]]
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[[Category: Phospho-fructose]]
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[[Category: Regulatory protein]]
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[[Category: Sis domain]]
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[[Category: Sugar binding protein]]

Revision as of 13:33, 12 March 2014

Template:STRUCTURE 4msu

Contents

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate

Template:ABSTRACT PUBMED 24405172

Function

[GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.

About this Structure

4msu is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ashton KS, Andrews KL, Bryan MC, Chen J, Chen K, Chen M, Chmait S, Croghan M, Cupples R, Fotsch C, Helmering J, Jordan SR, Kurzeja RJ, Michelsen K, Pennington LD, Poon SF, Sivits G, Van G, Vonderfecht SL, Wahl RC, Zhang J, Lloyd DJ, Hale C, St Jean DJ Jr. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem. 2014 Jan 23;57(2):309-24. doi: 10.1021/jm4016735. Epub 2014 Jan 9. PMID:24405172 doi:http://dx.doi.org/10.1021/jm4016735

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OCA

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