4eqk

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[[Image:4eqk.jpg|left|200px]]
 
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{{STRUCTURE_4eqk| PDB=4eqk | SCENE= }}
{{STRUCTURE_4eqk| PDB=4eqk | SCENE= }}
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===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP===
===Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP===
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{{ABSTRACT_PUBMED_23436652}}
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==Function==
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[[http://www.uniprot.org/uniprot/PB2_I68A4 PB2_I68A4]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
==About this Structure==
==About this Structure==
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[[4eqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/hong_kong/1/1968(h3n2)) Influenza a virus (a/hong kong/1/1968(h3n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQK OCA].
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[[4eqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I68a4 I68a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQK OCA].
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==Reference==
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<ref group="xtra">PMID:023436652</ref><references group="xtra"/><references/>
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[[Category: I68a4]]
[[Category: Liu, Y.]]
[[Category: Liu, Y.]]
[[Category: Meng, G.]]
[[Category: Meng, G.]]

Revision as of 13:42, 12 March 2014

Template:STRUCTURE 4eqk

Contents

Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Hong Kong/1/68 (h3n2) with bound m7GTP

Template:ABSTRACT PUBMED 23436652

Function

[PB2_I68A4] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).

About this Structure

4eqk is a 1 chain structure with sequence from I68a4. Full crystallographic information is available from OCA.

Reference

  • Liu Y, Qin K, Meng G, Zhang J, Zhou J, Zhao G, Luo M, Zheng X. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. J Biol Chem. 2013 Apr 19;288(16):11013-23. doi: 10.1074/jbc.M112.392878. Epub, 2013 Feb 22. PMID:23436652 doi:10.1074/jbc.M112.392878

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