4ps4

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m (Protected "4ps4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ps4| PDB=4ps4 | SCENE= }}
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===Crystal structure of the complex between IL-13 and M1295 FAB===
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{{ABSTRACT_PUBMED_20226193}}
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The entry 4ps4 is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
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Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
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==Function==
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[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
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Description: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN IL-13 AND M1295 FAB
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==About this Structure==
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[[4ps4]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3l5y 3l5y]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PS4 OCA].
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==Reference==
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<ref group="xtra">PMID:020226193</ref><references group="xtra"/><references/>
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[[Category: Gilliland, G L.]]
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[[Category: Malia, T.]]
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[[Category: Obmolova, G.]]
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[[Category: Teplyakov, A.]]
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[[Category: Alpha-helical bundle]]
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[[Category: Cytokine]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin fold]]
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[[Category: Monoclonal antibody]]
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[[Category: Secreted]]

Revision as of 08:40, 19 March 2014

Template:STRUCTURE 4ps4

Contents

Crystal structure of the complex between IL-13 and M1295 FAB

Template:ABSTRACT PUBMED 20226193

Disease

[IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Function

[IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

About this Structure

4ps4 is a 3 chain structure. This structure supersedes the now removed PDB entry 3l5y. Full crystallographic information is available from OCA.

Reference

  • Fransson J, Teplyakov A, Raghunathan G, Chi E, Cordier W, Dinh T, Feng Y, Giles-Komar J, Gilliland G, Lollo B, Malia TJ, Nishioka W, Obmolova G, Zhao S, Zhao Y, Swanson RV, Almagro JC. Human framework adaptation of a mouse anti-human IL-13 antibody. J Mol Biol. 2010 Apr 30;398(2):214-31. Epub 2010 Mar 10. PMID:20226193 doi:10.1016/j.jmb.2010.03.004

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