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4hpd

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'''Unreleased structure'''
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{{STRUCTURE_4hpd| PDB=4hpd | SCENE= }}
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===Crystal structure of Nitrophorin 4 from Rhodnius prolixus Complexed with homocysteine at pH 7.4===
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{{ABSTRACT_PUBMED_23474537}}
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The entry 4hpd is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
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Authors: Nishikawa, K., Ogata, H., Knipp, M.
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==About this Structure==
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[[4hpd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HPD OCA].
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Description: Crystal structure of Nitrophorin 4 from Rhodnius prolixus Complexed with homocysteine at pH 7.4
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==Reference==
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<ref group="xtra">PMID:023474537</ref><references group="xtra"/><references/>
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[[Category: Rhopr]]
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[[Category: Knipp, M.]]
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[[Category: Nishikawa, K.]]
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[[Category: Ogata, H.]]
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[[Category: Heme]]
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[[Category: Lipocalin]]
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[[Category: Metal binding protein]]
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[[Category: Nitrophorin]]
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[[Category: Transport protein]]

Revision as of 09:03, 19 March 2014

Template:STRUCTURE 4hpd

Contents

Crystal structure of Nitrophorin 4 from Rhodnius prolixus Complexed with homocysteine at pH 7.4

Template:ABSTRACT PUBMED 23474537

Function

[NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).

About this Structure

4hpd is a 1 chain structure with sequence from Rhopr. Full crystallographic information is available from OCA.

Reference

  • He C, Nishikawa K, Erdem OF, Reijerse E, Ogata H, Lubitz W, Knipp M. Complexes of ferriheme nitrophorin 4 with low-molecular weight thiol(ate)s occurring in blood plasma. J Inorg Biochem. 2013 May;122:38-48. doi: 10.1016/j.jinorgbio.2013.01.012. Epub, 2013 Feb 4. PMID:23474537 doi:http://dx.doi.org/10.1016/j.jinorgbio.2013.01.012

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OCA

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