This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4m0q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4m0q| PDB=4m0q | SCENE= }}
 +
===Ebola virus VP24 structure===
-
The entry 4m0q is ON HOLD until Aug 01 2015
+
==Function==
 +
[[http://www.uniprot.org/uniprot/VP24_EBOZM VP24_EBOZM]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.<ref>PMID:12191476</ref> <ref>PMID:12525613</ref> <ref>PMID:15220407</ref> <ref>PMID:17928350</ref>
-
Authors: Xu, W., Leung, D.W., Borek, D., Amarasinghe, G.K.
+
==About this Structure==
 +
[[4m0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0Q OCA].
-
Description: Ebola virus VP24 structure
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Amarasinghe, G K.]]
 +
[[Category: Borek, D.]]
 +
[[Category: Leung, D W.]]
 +
[[Category: Xu, W.]]
 +
[[Category: Ebola virus virulence factor]]
 +
[[Category: Viral protein]]

Revision as of 09:35, 19 March 2014

Template:STRUCTURE 4m0q

Contents

Ebola virus VP24 structure

Function

[VP24_EBOZM] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.[1] [2] [3] [4]

About this Structure

4m0q is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Huang Y, Xu L, Sun Y, Nabel GJ. The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein. Mol Cell. 2002 Aug;10(2):307-16. PMID:12191476
  2. ↑ Han Z, Boshra H, Sunyer JO, Zwiers SH, Paragas J, Harty RN. Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding. J Virol. 2003 Feb;77(3):1793-800. PMID:12525613
  3. ↑ Licata JM, Johnson RF, Han Z, Harty RN. Contribution of ebola virus glycoprotein, nucleoprotein, and VP24 to budding of VP40 virus-like particles. J Virol. 2004 Jul;78(14):7344-51. PMID:15220407 doi:http://dx.doi.org/10.1128/JVI.78.14.7344-7351.2004
  4. ↑ Reid SP, Valmas C, Martinez O, Sanchez FM, Basler CF. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. J Virol. 2007 Dec;81(24):13469-77. Epub 2007 Oct 10. PMID:17928350 doi:http://dx.doi.org/10.1128/JVI.01097-07

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4m0q"
Personal tools