4bw3

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==About this Structure==
==About this Structure==
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[[4bw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW3 OCA].
+
[[4bw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BW3 OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024000170</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024000170</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Bamborough, P.]]
[[Category: Bamborough, P.]]
[[Category: Bouillot, A.]]
[[Category: Bouillot, A.]]

Revision as of 09:49, 19 March 2014

Template:STRUCTURE 4bw3

Contents

The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand

Template:ABSTRACT PUBMED 24000170

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4bw3 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Mirguet O, Lamotte Y, Chung CW, Bamborough P, Delannee D, Bouillot A, Gellibert F, Krysa G, Lewis A, Witherington J, Huet P, Dudit Y, Trottet L, Nicodeme E. Naphthyridines as Novel BET Family Bromodomain Inhibitors. ChemMedChem. 2013 Sep 2. doi: 10.1002/cmdc.201300259. PMID:24000170 doi:10.1002/cmdc.201300259
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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