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4ov2

From Proteopedia

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m (Protected "4ov2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ov2| PDB=4ov2 | SCENE= }}
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===Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus===
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The entry 4ov2 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref>
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Authors: Pandaleneni, S., Burgoyne, R., Mayans, O., Lian, L.-Y.
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==About this Structure==
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[[4ov2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OV2 OCA].
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Description: Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Burgoyne, R.]]
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[[Category: Lian, L Y.]]
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[[Category: Mayans, O.]]
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[[Category: Pandaleneni, S.]]
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[[Category: Calcium binding protein]]

Revision as of 09:40, 26 March 2014

Template:STRUCTURE 4ov2

Contents

Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus

Function

[NCS1_RAT] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.[1]

About this Structure

4ov2 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Gambino F, Pavlowsky A, Begle A, Dupont JL, Bahi N, Courjaret R, Gardette R, Hadjkacem H, Skala H, Poulain B, Chelly J, Vitale N, Humeau Y. IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9063-8. Epub 2007 May 14. PMID:17502602 doi:http://dx.doi.org/10.1073/pnas.0701133104

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