966c
From Proteopedia
(New page: 200px<br /> <applet load="966c" size="450" color="white" frame="true" align="right" spinBox="true" caption="966c, resolution 1.9Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:966c.gif|left|200px]]<br /> | + | [[Image:966c.gif|left|200px]]<br /><applet load="966c" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="966c" size=" | + | |
caption="966c, resolution 1.9Å" /> | caption="966c, resolution 1.9Å" /> | ||
'''CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID'''<br /> | '''CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The X-ray crystal structures of the catalytic domain of human | + | The X-ray crystal structures of the catalytic domain of human collagenase-3 (MMP-13) and collagenase-1 (MMP-1) with bound inhibitors provides a basis for understanding the selectivity profile of a novel series of matrix metalloprotease (MMP) inhibitors. Differences in the relative size and shape of the MMP S1' pockets suggest that this pocket is a critical determinant of MMP inhibitor selectivity. The collagenase-3 S1' pocket is long and open, easily accommodating large P1' groups, such as diphenylether. In contrast, the collagenase-1 S1' pocket must undergo a conformational change to accommodate comparable P1' groups. The selectivity of the diphenylether series of inhibitors for collagenase-3 is largely determined by their affinity for the preformed S1' pocket of collagenase-3, as compared to the induced fit in collagenase-1. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 966C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA and RS2 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 966C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=RS2:'>RS2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=966C OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Broka, C.]] | [[Category: Broka, C.]] | ||
| - | [[Category: Browner, M | + | [[Category: Browner, M F.]] |
[[Category: Campbell, J.]] | [[Category: Campbell, J.]] | ||
[[Category: Carr, S.]] | [[Category: Carr, S.]] | ||
| - | [[Category: Hendricks, R | + | [[Category: Hendricks, R T.]] |
[[Category: Lovejoy, B.]] | [[Category: Lovejoy, B.]] | ||
[[Category: Luong, C.]] | [[Category: Luong, C.]] | ||
[[Category: Martin, R.]] | [[Category: Martin, R.]] | ||
[[Category: Walker, K.]] | [[Category: Walker, K.]] | ||
| - | [[Category: Wart, H | + | [[Category: Wart, H Van.]] |
[[Category: Welch, A.]] | [[Category: Welch, A.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: matrix metalloprotease]] | [[Category: matrix metalloprotease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:18:22 2008'' |
Revision as of 17:18, 21 February 2008
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CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID
Contents |
Overview
The X-ray crystal structures of the catalytic domain of human collagenase-3 (MMP-13) and collagenase-1 (MMP-1) with bound inhibitors provides a basis for understanding the selectivity profile of a novel series of matrix metalloprotease (MMP) inhibitors. Differences in the relative size and shape of the MMP S1' pockets suggest that this pocket is a critical determinant of MMP inhibitor selectivity. The collagenase-3 S1' pocket is long and open, easily accommodating large P1' groups, such as diphenylether. In contrast, the collagenase-1 S1' pocket must undergo a conformational change to accommodate comparable P1' groups. The selectivity of the diphenylether series of inhibitors for collagenase-3 is largely determined by their affinity for the preformed S1' pocket of collagenase-3, as compared to the induced fit in collagenase-1.
Disease
Known diseases associated with this structure: COPD, rate of decline of lung function in OMIM:[120353]
About this Structure
966C is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors., Lovejoy B, Welch AR, Carr S, Luong C, Broka C, Hendricks RT, Campbell JA, Walker KA, Martin R, Van Wart H, Browner MF, Nat Struct Biol. 1999 Mar;6(3):217-21. PMID:10074939
Page seeded by OCA on Thu Feb 21 19:18:22 2008
Categories: Homo sapiens | Single protein | Broka, C. | Browner, M F. | Campbell, J. | Carr, S. | Hendricks, R T. | Lovejoy, B. | Luong, C. | Martin, R. | Walker, K. | Wart, H Van. | Welch, A. | CA | RS2 | ZN | Matrix metalloprotease
