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4n0e
From Proteopedia
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{{STRUCTURE_4n0e| PDB=4n0e | SCENE= }} | {{STRUCTURE_4n0e| PDB=4n0e | SCENE= }} | ||
===Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP=== | ===Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP=== | ||
| + | {{ABSTRACT_PUBMED_24596087}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4n0e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0E OCA]. | [[4n0e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0E OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Guanine nucleotide-binding protein|Guanine nucleotide-binding protein]] | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024596087</ref><references group="xtra"/><references/> |
[[Category: Heterotrimeric G-protein GTPase]] | [[Category: Heterotrimeric G-protein GTPase]] | ||
[[Category: Hamm, H E.]] | [[Category: Hamm, H E.]] | ||
Revision as of 07:28, 2 April 2014
Contents |
Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP
Template:ABSTRACT PUBMED 24596087
Function
[GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.[1]
About this Structure
4n0e is a 1 chain structure. Full crystallographic information is available from OCA.
See Also
Reference
- Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM. A Transient Interaction Between the P-loop and Switch I Contributes to the Allosteric Network Between Receptor and Nucleotide in Galphai1. J Biol Chem. 2014 Mar 4. PMID:24596087 doi:http://dx.doi.org/10.1074/jbc.M113.539064
- ↑ Shu FJ, Ramineni S, Amyot W, Hepler JR. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cell Signal. 2007 Jan;19(1):163-76. Epub 2006 Jul 25. PMID:16870394 doi:http://dx.doi.org/10.1016/j.cellsig.2006.06.002
