4c9x

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'''Unreleased structure'''
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{{STRUCTURE_4c9x| PDB=4c9x | SCENE= }}
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===Crystal structure of NUDT1 (MTH1) with S-crizotinib===
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The entry 4c9x is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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Authors: Elkins, J.M., Salah, E., Huber, K., Superti-Furga, G., Abdul Azeez, K.R., Krojer, T., Von Delft, F., Bountra, C., Edwards, A., Knapp, S.
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==About this Structure==
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[[4c9x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9X OCA].
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Description: Crystal structure of NUDT1 (MTH1) with S-crizotinib
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Azeez, K R.Abdul.]]
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[[Category: Bountra, C.]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards, A.]]
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[[Category: Elkins, J M.]]
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[[Category: Huber, K.]]
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[[Category: Knapp, S.]]
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[[Category: Krojer, T.]]
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[[Category: Salah, E.]]
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[[Category: Superti-Furga, G.]]
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[[Category: Crizotinib]]
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[[Category: Hydrolase]]

Revision as of 09:28, 2 April 2014

Template:STRUCTURE 4c9x

Contents

Crystal structure of NUDT1 (MTH1) with S-crizotinib

Function

[8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.[1] [2] [3] [4] [5]

About this Structure

4c9x is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H. The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J Biol Chem. 1999 Jun 25;274(26):18201-5. PMID:10373420
  2. ↑ Fujii Y, Shimokawa H, Sekiguchi M, Nakabeppu Y. Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins. J Biol Chem. 1999 Dec 31;274(53):38251-9. PMID:10608900
  3. ↑ Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res. 2001 Jan 15;29(2):449-54. PMID:11139615
  4. ↑ Yoshimura D, Sakumi K, Ohno M, Sakai Y, Furuichi M, Iwai S, Nakabeppu Y. An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. J Biol Chem. 2003 Sep 26;278(39):37965-73. Epub 2003 Jul 10. PMID:12857738 doi:10.1074/jbc.M306201200
  5. ↑ Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. J Biol Chem. 2012 Jun 15;287(25):21541-9. doi: 10.1074/jbc.M112.363010. Epub 2012, May 3. PMID:22556419 doi:10.1074/jbc.M112.363010

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