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2npb

From Proteopedia

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[[Image:2npb.png|left|200px]]
 
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{{STRUCTURE_2npb| PDB=2npb | SCENE= }}
{{STRUCTURE_2npb| PDB=2npb | SCENE= }}
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===NMR solution structure of mouse SelW===
===NMR solution structure of mouse SelW===
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{{ABSTRACT_PUBMED_17928294}}
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{{ABSTRACT_PUBMED_17928294}}
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==Function==
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[[http://www.uniprot.org/uniprot/SELW_MOUSE SELW_MOUSE]] Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.<ref>PMID:12062442</ref> <ref>PMID:17503775</ref> <ref>PMID:16876868</ref>
==About this Structure==
==About this Structure==
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[[2npb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPB OCA].
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[[2npb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPB OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:017928294</ref><references group="xtra"/>
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<ref group="xtra">PMID:017928294</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
[[Category: Aachmann, F L.]]
[[Category: Aachmann, F L.]]
[[Category: Dikiy, A.]]
[[Category: Dikiy, A.]]

Revision as of 05:11, 9 April 2014

Template:STRUCTURE 2npb

Contents

NMR solution structure of mouse SelW

Template:ABSTRACT PUBMED 17928294

Function

[SELW_MOUSE] Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.[1] [2] [3]

About this Structure

2npb is a 1 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA.

Reference

  • Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21;282(51):37036-44. Epub 2007 Oct 10. PMID:17928294 doi:10.1074/jbc.M705410200
  1. ↑ Jeong Dw, Kim TS, Chung YW, Lee BJ, Kim IY. Selenoprotein W is a glutathione-dependent antioxidant in vivo. FEBS Lett. 2002 Apr 24;517(1-3):225-8. PMID:12062442
  2. ↑ Dikiy A, Novoselov SV, Fomenko DE, Sengupta A, Carlson BA, Cerny RL, Ginalski K, Grishin NV, Hatfield DL, Gladyshev VN. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry. 2007 Jun 12;46(23):6871-82. Epub 2007 May 16. PMID:17503775 doi:http://dx.doi.org/10.1021/bi602462q
  3. ↑ Loflin J, Lopez N, Whanger PD, Kioussi C. Selenoprotein W during development and oxidative stress. J Inorg Biochem. 2006 Oct;100(10):1679-84. Epub 2006 Jun 17. PMID:16876868 doi:http://dx.doi.org/10.1016/j.jinorgbio.2006.05.018

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