4omd

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'''Unreleased structure'''
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{{STRUCTURE_4omd| PDB=4omd | SCENE= }}
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===X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba===
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{{ABSTRACT_PUBMED_24666235}}
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The entry 4omd is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FURIN_HUMAN FURIN_HUMAN]] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.<ref>PMID:7690548</ref>
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Authors: Dahms, S.O., Than, M.E.
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==About this Structure==
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[[4omd]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMD OCA].
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Description: X-ray structure of human furin in complex with the competitive inhibitor Phac-RVRR-Amba
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==Reference==
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<ref group="xtra">PMID:024666235</ref><references group="xtra"/><references/>
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[[Category: Furin]]
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[[Category: Dahms, S O.]]
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[[Category: Than, M E.]]
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[[Category: Competitive inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Pro-protein convertase]]
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[[Category: Protease-inhibitor complex]]
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[[Category: Serine protease]]

Revision as of 06:24, 9 April 2014

Template:STRUCTURE 4omd

Contents

X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba

Template:ABSTRACT PUBMED 24666235

Function

[FURIN_HUMAN] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.[1]

About this Structure

4omd is a 12 chain structure. Full crystallographic information is available from OCA.

Reference

  • Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME. X-ray Structures of Human Furin in Complex with Competitive Inhibitors. ACS Chem Biol. 2014 Apr 1. PMID:24666235 doi:http://dx.doi.org/10.1021/cb500087x
  1. ↑ Takahashi S, Kasai K, Hatsuzawa K, Kitamura N, Misumi Y, Ikehara Y, Murakami K, Nakayama K. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. Biochem Biophys Res Commun. 1993 Sep 15;195(2):1019-26. PMID:7690548 doi:http://dx.doi.org/10.1006/bbrc.1993.2146

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