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4nft

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4nft| PDB=4nft | SCENE= }}
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===Crystal structure of human lnkH2B-h2A.Z-Anp32e===
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{{ABSTRACT_PUBMED_24613878}}
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The entry 4nft is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/H2B2E_HUMAN H2B2E_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/AN32E_HUMAN AN32E_HUMAN]] Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity (By similarity).
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Authors: Shan, S., Pan, L., Mao, Z., Wang, W., Sun, J., Dong, Q., Liang, X., Ding, X., Chen, S., Dai, L., Zhang, Z., Zhu, B., Zhou, Z.
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==About this Structure==
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[[4nft]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFT OCA].
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Description: Crystal structure of human lnkH2B-h2A.Z-Anp32e
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==Reference==
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<ref group="xtra">PMID:024613878</ref><references group="xtra"/><references/>
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[[Category: Chen, S.]]
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[[Category: Dai, L.]]
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[[Category: Ding, X.]]
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[[Category: Dong, Q.]]
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[[Category: Liang, X.]]
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[[Category: Mao, Z.]]
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[[Category: Pan, L.]]
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[[Category: Shan, S.]]
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[[Category: Sun, J.]]
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[[Category: Wang, W.]]
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[[Category: Zhang, Z.]]
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[[Category: Zhou, Z.]]
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[[Category: Zhu, B.]]
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[[Category: Chaperone]]
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[[Category: Histone binding protein]]

Revision as of 06:30, 9 April 2014

Template:STRUCTURE 4nft

Contents

Crystal structure of human lnkH2B-h2A.Z-Anp32e

Template:ABSTRACT PUBMED 24613878

Function

[H2B2E_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[1] [2] [3] Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.[4] [5] [6] [AN32E_HUMAN] Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity (By similarity).

About this Structure

4nft is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Mao Z, Pan L, Wang W, Sun J, Shan S, Dong Q, Liang X, Dai L, Ding X, Chen S, Zhang Z, Zhu B, Zhou Z. Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z. Cell Res. 2014 Apr;24(4):389-99. doi: 10.1038/cr.2014.30. Epub 2014 Mar 11. PMID:24613878 doi:http://dx.doi.org/10.1038/cr.2014.30
  1. ↑ Kim HS, Cho JH, Park HW, Yoon H, Kim MS, Kim SC. Endotoxin-neutralizing antimicrobial proteins of the human placenta. J Immunol. 2002 Mar 1;168(5):2356-64. PMID:11859126
  2. ↑ Tollin M, Bergman P, Svenberg T, Jornvall H, Gudmundsson GH, Agerberth B. Antimicrobial peptides in the first line defence of human colon mucosa. Peptides. 2003 Apr;24(4):523-30. PMID:12860195
  3. ↑ Howell SJ, Wilk D, Yadav SP, Bevins CL. Antimicrobial polypeptides of the human colonic epithelium. Peptides. 2003 Nov;24(11):1763-70. PMID:15019208 doi:10.1016/j.peptides.2003.07.028
  4. ↑ Kim HS, Cho JH, Park HW, Yoon H, Kim MS, Kim SC. Endotoxin-neutralizing antimicrobial proteins of the human placenta. J Immunol. 2002 Mar 1;168(5):2356-64. PMID:11859126
  5. ↑ Tollin M, Bergman P, Svenberg T, Jornvall H, Gudmundsson GH, Agerberth B. Antimicrobial peptides in the first line defence of human colon mucosa. Peptides. 2003 Apr;24(4):523-30. PMID:12860195
  6. ↑ Howell SJ, Wilk D, Yadav SP, Bevins CL. Antimicrobial polypeptides of the human colonic epithelium. Peptides. 2003 Nov;24(11):1763-70. PMID:15019208 doi:10.1016/j.peptides.2003.07.028

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