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4m5s

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'''Unreleased structure'''
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{{STRUCTURE_4m5s| PDB=4m5s | SCENE= }}
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===Human alphaB crystallin core domain in complex with C-terminal peptide===
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The entry 4m5s is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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Authors: Laganowsky, A., Cascio, D., Sawaya, M.R., Eisenberg, D.
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==Function==
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[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
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Description: Human alphaB crystallin core domain in complex with C-terminal peptide
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==About this Structure==
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[[4m5s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5S OCA].
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[[Category: Cascio, D.]]
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[[Category: Eisenberg, D.]]
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[[Category: Laganowsky, A.]]
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[[Category: Sawaya, M R.]]
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[[Category: Amyloid]]
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[[Category: Chaperone]]
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[[Category: Small heat shock protein]]

Revision as of 06:43, 9 April 2014

Template:STRUCTURE 4m5s

Contents

Human alphaB crystallin core domain in complex with C-terminal peptide

Disease

[CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

About this Structure

4m5s is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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