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1b7f
From Proteopedia
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{{STRUCTURE_1b7f| PDB=1b7f | SCENE= }} | {{STRUCTURE_1b7f| PDB=1b7f | SCENE= }} | ||
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===SXL-LETHAL PROTEIN/RNA COMPLEX=== | ===SXL-LETHAL PROTEIN/RNA COMPLEX=== | ||
| + | {{ABSTRACT_PUBMED_10217141}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/SXL_DROME SXL_DROME]] Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific product is expressed early only in female embryos and specifies female-adult specific splicing; in the male where it is not expressed, the default splicing gives rise to a truncated non-functional protein. The female-specific isoform specifies the splicing of its own transcript, thereby initiating a positive autoregulatory feedback loop leading to female development pathway. The female-specific isoform controls the sex-specific splicing of transformer (TRA); acts as a translational repressor for male-specific lethal-2 (MSL-2) and prevents male-less (MLE), MSL-1 and MSL-3 proteins from associating with the female X chromosome.<ref>PMID:3144435</ref> <ref>PMID:1710769</ref> <ref>PMID:1547493</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[1b7f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1b7f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B7F OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:010217141</ref>< | + | <ref group="xtra">PMID:010217141</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Drome]] |
[[Category: Handa, N.]] | [[Category: Handa, N.]] | ||
[[Category: Kim, I.]] | [[Category: Kim, I.]] | ||
Revision as of 06:30, 10 April 2014
Contents |
SXL-LETHAL PROTEIN/RNA COMPLEX
Template:ABSTRACT PUBMED 10217141
Function
[SXL_DROME] Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific product is expressed early only in female embryos and specifies female-adult specific splicing; in the male where it is not expressed, the default splicing gives rise to a truncated non-functional protein. The female-specific isoform specifies the splicing of its own transcript, thereby initiating a positive autoregulatory feedback loop leading to female development pathway. The female-specific isoform controls the sex-specific splicing of transformer (TRA); acts as a translational repressor for male-specific lethal-2 (MSL-2) and prevents male-less (MLE), MSL-1 and MSL-3 proteins from associating with the female X chromosome.[1] [2] [3]
About this Structure
1b7f is a 4 chain structure with sequence from Drome. Full crystallographic information is available from OCA.
Reference
- Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S. Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein. Nature. 1999 Apr 15;398(6728):579-85. PMID:10217141 doi:10.1038/19242
- ↑ Bell LR, Maine EM, Schedl P, Cline TW. Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins. Cell. 1988 Dec 23;55(6):1037-46. PMID:3144435
- ↑ Samuels ME, Schedl P, Cline TW. The complex set of late transcripts from the Drosophila sex determination gene sex-lethal encodes multiple related polypeptides. Mol Cell Biol. 1991 Jul;11(7):3584-602. PMID:1710769
- ↑ Keyes LN, Cline TW, Schedl P. The primary sex determination signal of Drosophila acts at the level of transcription. Cell. 1992 Mar 6;68(5):933-43. PMID:1547493
Categories: Drome | Handa, N. | Kim, I. | Kurimoto, K. | Muto, Y. | Nureki, O. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Sakamoto, H. | Shimura, Y. | Yokoyama, S. | Riken structural genomics/proteomics initiative | Rna complex | Rna-binding protein-rna complex | Rnp domain | Rsgi | Splicing regulation | Structural genomic
