4nqw
From Proteopedia
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{{STRUCTURE_4nqw| PDB=4nqw | SCENE= }} | {{STRUCTURE_4nqw| PDB=4nqw | SCENE= }} | ||
===Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA=== | ===Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA=== | ||
| + | {{ABSTRACT_PUBMED_24699647}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4nqw]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. | + | [[4nqw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024699647</ref><references group="xtra"/><references/> | ||
[[Category: Gopal, B.]] | [[Category: Gopal, B.]] | ||
[[Category: Shukla, J K.]] | [[Category: Shukla, J K.]] | ||
Revision as of 07:33, 16 April 2014
Contents |
Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA
Template:ABSTRACT PUBMED 24699647
Function
[SIGK_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [RSKA_MYCTU] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.
About this Structure
4nqw is a 2 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. This structure supersedes the now removed PDB entry 3vdo. Full crystallographic information is available from OCA.
Reference
- Shukla J, Gupta R, Thakur KG, Gokhale R, Gopal B. Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA sigma-anti-sigma complex. Acta Crystallogr D Biol Crystallogr. 2014 Apr 1;70(Pt 4):1026-36. doi:, 10.1107/S1399004714000121. Epub 2014 Mar 19. PMID:24699647 doi:http://dx.doi.org/10.1107/S1399004714000121
