1e4e

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[[Image:1e4e.png|left|200px]]
 
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{{STRUCTURE_1e4e| PDB=1e4e | SCENE= }}
{{STRUCTURE_1e4e| PDB=1e4e | SCENE= }}
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===D-ALANYL-D-LACATE LIGASE===
===D-ALANYL-D-LACATE LIGASE===
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{{ABSTRACT_PUBMED_10908650}}
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==Function==
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[[http://www.uniprot.org/uniprot/VANA_ENTFC VANA_ENTFC]] Required for high-level resistance to glycopeptide antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin binding.<ref>PMID:1931965</ref>
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{{ABSTRACT_PUBMED_10908650}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:010908650</ref><ref group="xtra">PMID:016779845</ref><references group="xtra"/>
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<ref group="xtra">PMID:010908650</ref><references group="xtra"/><references/>
[[Category: Enterococcus faecium]]
[[Category: Enterococcus faecium]]
[[Category: Roper, D I.]]
[[Category: Roper, D I.]]

Revision as of 10:48, 16 April 2014

Template:STRUCTURE 1e4e

Contents

D-ALANYL-D-LACATE LIGASE

Template:ABSTRACT PUBMED 10908650

Function

[VANA_ENTFC] Required for high-level resistance to glycopeptide antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin binding.[1]

About this Structure

1e4e is a 2 chain structure with sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

  • Roper DI, Huyton T, Vagin A, Dodson G. The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA). Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8921-5. PMID:10908650 doi:http://dx.doi.org/10.1073/pnas.150116497
  1. ↑ Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry. 1991 Oct 29;30(43):10408-15. PMID:1931965

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