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1nu4

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[[Image:1nu4.png|left|200px]]
 
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{{STRUCTURE_1nu4| PDB=1nu4 | SCENE= }}
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===U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix===
===U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix===
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{{ABSTRACT_PUBMED_12876372}}
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==Function==
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[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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{{ABSTRACT_PUBMED_12876372}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012876372</ref><references group="xtra"/>
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<ref group="xtra">PMID:012876372</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Amare, A R.Ferre-D.]]

Revision as of 10:59, 16 April 2014

Template:STRUCTURE 1nu4

Contents

U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix

Template:ABSTRACT PUBMED 12876372

Function

[SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1]

About this Structure

1nu4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Rupert PB, Xiao H, Ferre-D'Amare AR. U1A RNA-binding domain at 1.8 A resolution. Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1521-4. Epub 2003, Jul 23. PMID:12876372
  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

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