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1j75
From Proteopedia
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{{STRUCTURE_1j75| PDB=1j75 | SCENE= }} | {{STRUCTURE_1j75| PDB=1j75 | SCENE= }} | ||
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===Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA=== | ===Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA=== | ||
| + | {{ABSTRACT_PUBMED_11524677}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ZBP1_MOUSE ZBP1_MOUSE]] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.<ref>PMID:17618271</ref> <ref>PMID:19590578</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:011524677</ref><references group="xtra"/> | + | <ref group="xtra">PMID:011524677</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Behlke, J.]] | [[Category: Behlke, J.]] | ||
Revision as of 11:00, 16 April 2014
Contents |
Crystal Structure of the DNA-Binding Domain Zalpha of DLM-1 Bound to Z-DNA
Template:ABSTRACT PUBMED 11524677
Function
[ZBP1_MOUSE] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.[1] [2]
About this Structure
1j75 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A. Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. Nat Struct Biol. 2001 Sep;8(9):761-5. PMID:11524677 doi:10.1038/nsb0901-761
- ↑ Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature. 2007 Jul 26;448(7152):501-5. Epub 2007 Jul 8. PMID:17618271 doi:http://dx.doi.org/10.1038/nature06013
- ↑ Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009 Aug;10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10. PMID:19590578 doi:http://dx.doi.org/10.1038/embor.2009.109
