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4mfv

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{{STRUCTURE_4mfv| PDB=4mfv | SCENE= }}
{{STRUCTURE_4mfv| PDB=4mfv | SCENE= }}
===Crystal structure of human CTNNBL1(residues 33~563)===
===Crystal structure of human CTNNBL1(residues 33~563)===
 +
{{ABSTRACT_PUBMED_24598747}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
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[[4mfv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFV OCA].
+
[[4mfv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MFV OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024598747</ref><references group="xtra"/><references/>
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[[Category: Human]]
[[Category: Ahn, J W.]]
[[Category: Ahn, J W.]]
[[Category: Kim, K J.]]
[[Category: Kim, K J.]]

Revision as of 06:29, 23 April 2014

Template:STRUCTURE 4mfv

Contents

Crystal structure of human CTNNBL1(residues 33~563)

Template:ABSTRACT PUBMED 24598747

Function

[CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.[1] [2]

About this Structure

4mfv is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ. Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi:, 10.1107/S139900471303318X. Epub 2014 Feb 22. PMID:24598747 doi:http://dx.doi.org/10.1107/S139900471303318X
  1. ↑ Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics. 2003 Mar;81(3):292-303. PMID:12659813
  2. ↑ Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009. PMID:18722174 doi:10.1016/j.molcel.2008.07.009

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