3g7t
From Proteopedia
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{{STRUCTURE_3g7t| PDB=3g7t | SCENE= }} | {{STRUCTURE_3g7t| PDB=3g7t | SCENE= }} | ||
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===Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation=== | ===Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation=== | ||
| + | {{ABSTRACT_PUBMED_19244332}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/Q5USP2_9FLAV Q5USP2_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774] | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019244332</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019244332</ref><references group="xtra"/><references/> |
[[Category: Dengue virus 1]] | [[Category: Dengue virus 1]] | ||
[[Category: Modis, Y.]] | [[Category: Modis, Y.]] | ||
Revision as of 06:51, 23 April 2014
Contents |
Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation
Template:ABSTRACT PUBMED 19244332
Function
[Q5USP2_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]
About this Structure
3g7t is a 1 chain structure with sequence from Dengue virus 1. Full crystallographic information is available from OCA.
Reference
- Nayak V, Dessau M, Kucera K, Anthony K, Ledizet M, Modis Y. Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion. J Virol. 2009 May;83(9):4338-44. Epub 2009 Feb 25. PMID:19244332 doi:10.1128/JVI.02574-08
