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4ndw

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ndw| PDB=4ndw | SCENE= }}
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===Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)===
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{{ABSTRACT_PUBMED_24699733}}
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The entry 4ndw is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU]] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>
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Authors: Gangwar, S.P., Meena, S.R., Saxena, A.K.
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==About this Structure==
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[[4ndw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDW OCA].
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Description: Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)
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==Reference==
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<ref group="xtra">PMID:024699733</ref><references group="xtra"/><references/>
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[[Category: Gangwar, S P.]]
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[[Category: Meena, S R.]]
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[[Category: Saxena, A K.]]
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[[Category: All helical]]
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[[Category: Dna binding]]
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[[Category: Helix-turn-helix motif]]
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[[Category: Transactional regulator]]
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[[Category: Transcription]]

Revision as of 07:38, 23 April 2014

Template:STRUCTURE 4ndw

Contents

Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)

Template:ABSTRACT PUBMED 24699733

Function

[ESPR_MYCTU] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.[1] [2] [3] [4]

About this Structure

4ndw is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gangwar SP, Meena SR, Saxena AK. Comparison of four different crystal forms of the Mycobacterium tuberculosis ESX-1 secreted protein regulator EspR. Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):433-7. doi:, 10.1107/S2053230X14004166. Epub 2014 Mar 25. PMID:24699733 doi:http://dx.doi.org/10.1107/S2053230X14004166
  1. ↑ Raghavan S, Manzanillo P, Chan K, Dovey C, Cox JS. Secreted transcription factor controls Mycobacterium tuberculosis virulence. Nature. 2008 Aug 7;454(7205):717-21. doi: 10.1038/nature07219. PMID:18685700 doi:http://dx.doi.org/10.1038/nature07219
  2. ↑ Hunt DM, Sweeney NP, Mori L, Whalan RH, Comas I, Norman L, Cortes T, Arnvig KB, Davis EO, Stapleton MR, Green J, Buxton RS. Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis. J Bacteriol. 2012 May;194(9):2307-20. doi: 10.1128/JB.00142-12. Epub 2012 Mar 2. PMID:22389481 doi:http://dx.doi.org/10.1128/JB.00142-12
  3. ↑ Blasco B, Chen JM, Hartkoorn R, Sala C, Uplekar S, Rougemont J, Pojer F, Cole ST. Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein. PLoS Pathog. 2012;8(3):e1002621. doi: 10.1371/journal.ppat.1002621. Epub 2012 Mar, 29. PMID:22479184 doi:http://dx.doi.org/10.1371/journal.ppat.1002621
  4. ↑ Blasco B, Stenta M, Alonso-Sarduy L, Dietler G, Peraro MD, Cole ST, Pojer F. Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis. Mol Microbiol. 2011 Aug 30. doi: 10.1111/j.1365-2958.2011.07813.x. PMID:21883526 doi:10.1111/j.1365-2958.2011.07813.x

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