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4kr9

From Proteopedia

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m (Protected "4kr9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kr9| PDB=4kr9 | SCENE= }}
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===Crystal structure of a 4-thiouridine synthetase - RNA complex at 3.5 Angstrom resolution===
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{{ABSTRACT_PUBMED_24705700}}
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The entry 4kr9 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/THII_THEMA THII_THEMA]] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
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Authors: Neumann, P., Ficner, R., Lakomek, K.
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==About this Structure==
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[[4kr9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KR9 OCA].
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Description: Crystal structure of a 4-thiouridine synthetase -RNA complex at 3.5 Angstrom resolution
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==Reference==
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<ref group="xtra">PMID:024705700</ref><references group="xtra"/><references/>
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[[Category: TRNA sulfurtransferase]]
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[[Category: Ficner, R.]]
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[[Category: Lakomek, K.]]
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[[Category: Neumann, P.]]
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[[Category: 4-thiouridine synthesis]]
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[[Category: Adenylation]]
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[[Category: Pp-loop motif]]
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[[Category: Sulfurtransferase]]
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[[Category: Thiouridine]]
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[[Category: Thump domain]]
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[[Category: Transferase-rna complex]]
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[[Category: Trna modification]]

Revision as of 07:44, 23 April 2014

Template:STRUCTURE 4kr9

Contents

Crystal structure of a 4-thiouridine synthetase - RNA complex at 3.5 Angstrom resolution

Template:ABSTRACT PUBMED 24705700

Function

[THII_THEMA] Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).

About this Structure

4kr9 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Neumann P, Lakomek K, Naumann PT, Erwin WM, Lauhon CT, Ficner R. Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification. Nucleic Acids Res. 2014 Apr 5. PMID:24705700 doi:http://dx.doi.org/10.1093/nar/gku249

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OCA

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