1v6b
From Proteopedia
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{{STRUCTURE_1v6b| PDB=1v6b | SCENE= }} | {{STRUCTURE_1v6b| PDB=1v6b | SCENE= }} | ||
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===Solution structure of the third PDZ domain of mouse harmonin=== | ===Solution structure of the third PDZ domain of mouse harmonin=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/USH1C_MOUSE USH1C_MOUSE]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:19447093</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[1v6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6B OCA]. | [[1v6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6B OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Inoue, M.]] | [[Category: Inoue, M.]] | ||
Revision as of 08:27, 23 April 2014
Contents |
Solution structure of the third PDZ domain of mouse harmonin
Function
[USH1C_MOUSE] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.[1]
About this Structure
1v6b is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.
Reference
- ↑ Grillet N, Xiong W, Reynolds A, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, Muller U. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron. 2009 May 14;62(3):375-87. doi: 10.1016/j.neuron.2009.04.006. PMID:19447093 doi:http://dx.doi.org/10.1016/j.neuron.2009.04.006
